Black Seed (Nigella sativa) Efficacy in Improving Clinical Symptoms and Interleukin-6 Levels Schizophrenic Patients

BACKGROUND: Schizophrenia with a global prevalence of 0.33–0.75% and one the top 15 causes disability. The etiology underlying this disease is still controversial. One Vulnerability Stress-Schizophrenia Inflammatory Model which shows an increase in pro-inflammatory cytokines, Interleukin-6 (IL-6). AIM: It hoped that through adjuvant anti-inflammatory effect black seed or Nigella sativa can improve clinical symptoms schizophrenia reduce levels Serum IL-6 as marker therapeutic efficacy, well observing treatment on liver function. METHODS: present study was conducted 22 schizophrenic patients hospitalized at psychiatric hospital (Rumah Sakit Khusus Daerah) South Sulawesi aged 20–45 years received risperidone 4 mg/day therapy. Patients were divided into two groups, control groups N. 1000 mg/d for weeks. Each group measured baseline week Positive Negative Symptom (PANSS) serum levels. analysis also 14 healthy people by assessing side effects adjuvants measuring function enzymes Glutamic Oxaloacetic Transaminase (SGOT) Pyruvic (SGPT). RESULTS: higher than controls. Administration mg weeks significantly p < 0.001 improved PANSS value, decreased 2.5 times faster did not give significant change SGOT SGPT values. CONCLUSION: This suggests may consider therapy to safe